A stretch of polybasic residues mediates Cdc42 GTPase-activating protein (CdGAP) binding to phosphatidylinositol 3,4,5-trisphosphate and regulates its GAP activity.

Karimzadeh, Fereshteh; Primeau, Martin; Mountassif, Driss; Rouiller, Isabelle; Lamarche-Vane, Nathalie

Karimzadeh, Fereshteh; Primeau, Martin; Mountassif, Driss; Rouiller, Isabelle; Lamarche-Vane, Nathalie.

Affiliation

Karimzadeh F; Department of Anatomy and Cell Biology, McGill University, Montreal, Quebec H3A 2B2, Canada.

J Biol Chem ; 287(23): 19610-21, 2012 Jun 01.

Article in En | MEDLINE | ID: mdl-22518840

Subject(s)

GTPase-Activating Proteins/metabolism; Phosphatidylinositol Phosphates/metabolism; Phosphoproteins/metabolism; Signal Transduction; cdc42 GTP-Binding Protein/metabolism; rac1 GTP-Binding Protein/metabolism; Amino Acid Sequence; Animals; Breast Neoplasms/genetics; Breast Neoplasms/metabolism; COS Cells; Cell Adhesion/genetics; Cell Line, Tumor; Chlorocebus aethiops; Female; Fibroblasts/metabolism; GTPase-Activating Proteins/genetics; HEK293 Cells; Humans; Mutation; Phosphatidylinositol Phosphates/genetics; Phosphoproteins/genetics; Protein Structure, Tertiary; Receptor, ErbB-2/genetics; Receptor, ErbB-2/metabolism; Transforming Growth Factor beta/genetics; Transforming Growth Factor beta/metabolism; cdc42 GTP-Binding Protein/genetics; rac1 GTP-Binding Protein/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phosphoproteins / Signal Transduction / Phosphatidylinositol Phosphates / Cdc42 GTP-Binding Protein / Rac1 GTP-Binding Protein / GTPase-Activating Proteins Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: Canada

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