Mutant HSPB1 overexpression in neurons is sufficient to cause age-related motor neuronopathy in mice.

Srivastava, Amit K; Renusch, Samantha R; Naiman, Nicole E; Gu, Shuping; Sneh, Amita; Arnold, W David; Sahenk, Zarife; Kolb, Stephen J

Srivastava, Amit K; Renusch, Samantha R; Naiman, Nicole E; Gu, Shuping; Sneh, Amita; Arnold, W David; Sahenk, Zarife; Kolb, Stephen J.

Affiliation

Srivastava AK; Center for RNA Biology and Department of Molecular & Cellular Biochemistry, The Ohio State University Medical Center, Columbus, OH 43210-1228, USA.

Neurobiol Dis ; 47(2): 163-73, 2012 Aug.

Article in En | MEDLINE | ID: mdl-22521462

Subject(s)

Aging/metabolism; Charcot-Marie-Tooth Disease/metabolism; Gene Expression Regulation; HSP27 Heat-Shock Proteins/genetics; Motor Neurons/metabolism; Mutation/physiology; Aging/pathology; Animals; Axons/pathology; Charcot-Marie-Tooth Disease/pathology; HSP27 Heat-Shock Proteins/biosynthesis; Heat-Shock Proteins; Humans; Mice; Mice, Transgenic; Molecular Chaperones; Motor Neuron Disease/metabolism; Motor Neuron Disease/pathology; Motor Neurons/pathology; Random Allocation

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Aging / Charcot-Marie-Tooth Disease / Gene Expression Regulation / HSP27 Heat-Shock Proteins / Motor Neurons / Mutation Type of study: Clinical_trials / Prognostic_studies Limits: Animals / Humans Language: En Journal: Neurobiol Dis Journal subject: NEUROLOGIA Year: 2012 Type: Article Affiliation country: United States

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