Primary progressive multiple sclerosis developing in the context of young onset Parkinson's disease.
Mult Scler
; 19(1): 123-5, 2013 Jan.
Article
in En
| MEDLINE
| ID: mdl-22523156
ABSTRACT
We report a patient with young onset Parkinson's disease (PD) and a heterozygous point mutation in parkin (c.1000C>T; p.Arg334Cys). After 8 years he developed pyramidal signs and reinvestigation demonstrated MRI and laboratory findings supportive of a diagnosis of multiple sclerosis (MS) with a primary progressive (PP) clinical course. This is a previously un-described association of young onset PD with PPMS. Imaging clearly dates the occurrence of each disease as chronologically separate phenomena. There is not currently evidence for shared causation or pathogenesis between the two neurological disorders but we will follow with interest the emerging genetic characterization of parkin in both PD and MS.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Parkinson Disease
/
Multiple Sclerosis, Chronic Progressive
Limits:
Adult
/
Humans
/
Male
Language:
En
Journal:
Mult Scler
Journal subject:
NEUROLOGIA
Year:
2013
Type:
Article
Affiliation country:
United kingdom