A pharmacodynamic model of ganciclovir antiviral effect and toxicity for lymphoblastoid cells suggests a new dosing regimen to treat cytomegalovirus infection.

Janoly-Dumenil, Audrey; Rouvet, Isabelle; Bleyzac, Nathalie; Morfin, Florence; Zabot, Marie-Therese; Tod, Michel

Janoly-Dumenil, Audrey; Rouvet, Isabelle; Bleyzac, Nathalie; Morfin, Florence; Zabot, Marie-Therese; Tod, Michel.

Affiliation

Janoly-Dumenil A; Hôpital Lyon-sud, Hospices Civils de Lyon, Lyon, France.

Antimicrob Agents Chemother ; 56(7): 3732-8, 2012 Jul.

Article in En | MEDLINE | ID: mdl-22526305

Subject(s)

Antiviral Agents/adverse effects; Antiviral Agents/pharmacology; Cytomegalovirus Infections/virology; Cytomegalovirus/drug effects; Ganciclovir/adverse effects; Ganciclovir/pharmacology; Antiviral Agents/pharmacokinetics; Cell Survival/drug effects; Cells, Cultured; Ganciclovir/pharmacokinetics; Humans; Leukocytes, Mononuclear/cytology; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/virology; Models, Theoretical

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Ganciclovir / Cytomegalovirus Infections / Cytomegalovirus Limits: Humans Language: En Journal: Antimicrob Agents Chemother Year: 2012 Type: Article Affiliation country: France

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