MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells.

Nishida, Chiemi; Kusubata, Kaori; Tashiro, Yoshihiko; Gritli, Ismael; Sato, Aki; Ohki-Koizumi, Makiko; Morita, Yohei; Nagano, Makoto; Sakamoto, Takeharu; Koshikawa, Naohiko; Kuchimaru, Takahiro; Kizaka-Kondoh, Shinae; Seiki, Motoharu; Nakauchi, Hiromitsu; Heissig, Beate; Hattori, Koichi

Nishida, Chiemi; Kusubata, Kaori; Tashiro, Yoshihiko; Gritli, Ismael; Sato, Aki; Ohki-Koizumi, Makiko; Morita, Yohei; Nagano, Makoto; Sakamoto, Takeharu; Koshikawa, Naohiko; Kuchimaru, Takahiro; Kizaka-Kondoh, Shinae; Seiki, Motoharu; Nakauchi, Hiromitsu; Heissig, Beate; Hattori, Koichi.

Affiliation

Nishida C; Center for Stem Cell Biology and Regenerative Medicine, Institute of Medical Science, University of Tokyo, Tokyo, Japan.

Blood ; 119(23): 5405-16, 2012 Jun 07.

Article in En | MEDLINE | ID: mdl-22544701

Subject(s)

Cytokines/genetics; Hematopoiesis; Hematopoietic Stem Cells/cytology; Hypoxia-Inducible Factor 1/metabolism; Matrix Metalloproteinase 14/metabolism; Transcriptional Activation; Animals; B-Lymphocytes/cytology; B-Lymphocytes/metabolism; Cell Line; Cells, Cultured; Chemokine CXCL12/metabolism; Chemokines/genetics; Erythroid Cells/cytology; Erythroid Cells/metabolism; Gene Deletion; Hematopoietic Stem Cells/metabolism; Humans; Matrix Metalloproteinase 14/genetics; Mice; Mice, Inbred C57BL; Stem Cell Factor/metabolism; Stromal Cells/cytology; Stromal Cells/metabolism; T-Lymphocytes/cytology; T-Lymphocytes/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Hematopoietic Stem Cells / Transcriptional Activation / Cytokines / Hypoxia-Inducible Factor 1 / Matrix Metalloproteinase 14 / Hematopoiesis Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Blood Year: 2012 Type: Article Affiliation country: Japan

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