De novo DNA methylation is required to restrict T helper lineage plasticity.

Thomas, Rajan M; Gamper, Christopher J; Ladle, Brian H; Powell, Jonathan D; Wells, Andrew D

Thomas, Rajan M; Gamper, Christopher J; Ladle, Brian H; Powell, Jonathan D; Wells, Andrew D.

Affiliation

Thomas RM; Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine and The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104, USA.

J Biol Chem ; 287(27): 22900-9, 2012 Jun 29.

Article in En | MEDLINE | ID: mdl-22584578

Subject(s)

Cell Lineage/immunology; DNA Methylation/physiology; Homeostasis/immunology; T-Lymphocytes, Helper-Inducer/cytology; T-Lymphocytes, Helper-Inducer/immunology; Animals; Cell Differentiation/immunology; Cells, Cultured; Cytokines/genetics; Cytokines/immunology; DNA (Cytosine-5-)-Methyltransferases/genetics; DNA (Cytosine-5-)-Methyltransferases/metabolism; DNA Methyltransferase 3A; Epigenesis, Genetic/immunology; Gene Silencing/immunology; Interferon-gamma/genetics; Interferon-gamma/immunology; Mice; Mice, 129 Strain; Mice, Mutant Strains; Promoter Regions, Genetic/immunology; Signal Transduction/immunology; T-Lymphocytes, Regulatory/cytology; T-Lymphocytes, Regulatory/immunology; Th17 Cells/cytology; Th17 Cells/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: T-Lymphocytes, Helper-Inducer / Cell Lineage / DNA Methylation / Homeostasis Limits: Animals Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: United States

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