Iterative experimental and virtual high-throughput screening identifies metabotropic glutamate receptor subtype 4 positive allosteric modulators.

Mueller, Ralf; Dawson, Eric S; Niswender, Colleen M; Butkiewicz, Mariusz; Hopkins, Corey R; Weaver, C David; Lindsley, Craig W; Conn, P Jeffrey; Meiler, Jens

Mueller, Ralf; Dawson, Eric S; Niswender, Colleen M; Butkiewicz, Mariusz; Hopkins, Corey R; Weaver, C David; Lindsley, Craig W; Conn, P Jeffrey; Meiler, Jens.

Affiliation

Mueller R; Department of Chemistry, Vanderbilt University, Nashville, TN, 37232-6600, USA.

J Mol Model ; 18(9): 4437-46, 2012 Sep.

Article in En | MEDLINE | ID: mdl-22592386

Subject(s)

High-Throughput Screening Assays/methods; Receptors, Metabotropic Glutamate/metabolism; Small Molecule Libraries/analysis; Small Molecule Libraries/pharmacology; User-Computer Interface; Allosteric Regulation/drug effects; Animals; Benzoxazoles/analysis; Benzoxazoles/chemistry; Benzoxazoles/pharmacology; Humans; Models, Molecular; Neural Networks, Computer; Quantitative Structure-Activity Relationship; ROC Curve; Rats; Small Molecule Libraries/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: User-Computer Interface / Receptors, Metabotropic Glutamate / Small Molecule Libraries / High-Throughput Screening Assays Type of study: Diagnostic_studies / Prognostic_studies / Screening_studies Limits: Animals / Humans Language: En Journal: J Mol Model Journal subject: BIOLOGIA MOLECULAR Year: 2012 Type: Article Affiliation country: United States

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