Gammaherpesvirus latency accentuates EAE pathogenesis: relevance to Epstein-Barr virus and multiple sclerosis.

Casiraghi, Costanza; Shanina, Iryna; Cho, Sehyun; Freeman, Michael L; Blackman, Marcia A; Horwitz, Marc S

Casiraghi, Costanza; Shanina, Iryna; Cho, Sehyun; Freeman, Michael L; Blackman, Marcia A; Horwitz, Marc S.

Affiliation

Casiraghi C; Department of Microbiology and Immunology, The University of British Columbia, Vancouver, British Columbia, Canada.

PLoS Pathog ; 8(5): e1002715, 2012.

Article in En | MEDLINE | ID: mdl-22615572

Subject(s)

Brain/immunology; Encephalomyelitis, Autoimmune, Experimental/immunology; Encephalomyelitis, Autoimmune, Experimental/virology; Rhadinovirus/pathogenicity; Spinal Cord/immunology; Virus Latency; Animals; Brain/pathology; Brain/virology; CD4-Positive T-Lymphocytes/immunology; CD4-Positive T-Lymphocytes/virology; CD8-Positive T-Lymphocytes/immunology; CD8-Positive T-Lymphocytes/virology; Cells, Cultured; Encephalomyelitis, Autoimmune, Experimental/pathology; Herpesviridae Infections/immunology; Herpesviridae Infections/pathology; Herpesvirus 4, Human/pathogenicity; Interferon-gamma/biosynthesis; Interleukin-17/biosynthesis; Macrophages/immunology; Macrophages/virology; Mice; Mice, Inbred C57BL; Multiple Sclerosis/immunology; Multiple Sclerosis/virology; Spinal Cord/pathology; Spinal Cord/virology; T-Box Domain Proteins/biosynthesis; Th1 Cells/immunology; Th17 Cells/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Brain / Virus Latency / Rhadinovirus / Encephalomyelitis, Autoimmune, Experimental Type of study: Etiology_studies / Prognostic_studies Limits: Animals Language: En Journal: PLoS Pathog Year: 2012 Type: Article Affiliation country: Canada

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