Genome sequence of the first human adenovirus type 14 isolated in China.
J Virol
; 86(12): 7019-20, 2012 Jun.
Article
in En
| MEDLINE
| ID: mdl-22628402
ABSTRACT
Emergent pathogens may be examined rapidly at high resolution on a molecular level using genomics, allowing an understanding of their evolution. China is a unique environment for studying pathogens, having a large, dense, and generally closed population. Human adenovirus type 14 (HAdV-14) was originally identified as an acute respiratory disease (ARD) pathogen in The Netherlands (1955), with a second isolation in England (1957). Since then, few reports of this virus appeared until an ARD pathogen with a similar genome caused multiple outbreaks in the United States (2006 to 2009). This report presents the first genome of HAdV-B14 isolated in China (2010). As China experienced two recent outbreaks of an emergent ARD pathogen, HAdV-B55, containing much of the HAdV-B14 genome, the availability of this HAdV-B14 sequence will facilitate studies of the epidemiology of these pathogens, as well as provide a foundation for studying adenovirus evolution and the genesis of emergent pathogens. These observations may be invaluable in predicting possible recombination between wild-type viruses and adenoviral gene delivery vectors, including adenovirus vaccines.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Adenovirus Infections, Human
/
Adenoviruses, Human
/
Genome, Viral
Limits:
Humans
/
Infant
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
J Virol
Year:
2012
Type:
Article
Affiliation country:
China