Dynamic combinatorial chemistry employing boronic acids/boronate esters leads to potent oxygenase inhibitors.

Demetriades, Marina; Leung, Ivanhoe K H; Chowdhury, Rasheduzzaman; Chan, Mun Chiang; McDonough, Michael A; Yeoh, Kar Kheng; Tian, Ya-Min; Claridge, Timothy D W; Ratcliffe, Peter J; Woon, Esther C Y; Schofield, Christopher J

Demetriades, Marina; Leung, Ivanhoe K H; Chowdhury, Rasheduzzaman; Chan, Mun Chiang; McDonough, Michael A; Yeoh, Kar Kheng; Tian, Ya-Min; Claridge, Timothy D W; Ratcliffe, Peter J; Woon, Esther C Y; Schofield, Christopher J.

Affiliation

Demetriades M; Chemistry Research Laboratory, University of Oxford, 12 Mansfield Road, Oxford, OX1 3TA UK.

Angew Chem Int Ed Engl ; 51(27): 6672-5, 2012 Jul 02.

Article in En | MEDLINE | ID: mdl-22639232

Subject(s)

Boronic Acids/chemistry; Enzyme Inhibitors/chemistry; Esters/chemistry; Procollagen-Proline Dioxygenase/antagonists & inhibitors; Combinatorial Chemistry Techniques/methods; Humans; Hypoxia-Inducible Factor-Proline Dioxygenases; Kinetics; Mass Spectrometry/methods; Nuclear Magnetic Resonance, Biomolecular/methods; Oxidation-Reduction; Procollagen-Proline Dioxygenase/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Boronic Acids / Procollagen-Proline Dioxygenase / Enzyme Inhibitors / Esters Limits: Humans Language: En Journal: Angew Chem Int Ed Engl Year: 2012 Type: Article

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