Neonatal mice genetically modified to express the elastase inhibitor elafin are protected against the adverse effects of mechanical ventilation on lung growth.

Hilgendorff, Anne; Parai, Kakoli; Ertsey, Robert; Juliana Rey-Parra, G; Thébaud, Bernard; Tamosiuniene, Rasa; Jain, Noopur; Navarro, Edwin F; Starcher, Barry C; Nicolls, Mark R; Rabinovitch, Marlene; Bland, Richard D

Hilgendorff, Anne; Parai, Kakoli; Ertsey, Robert; Juliana Rey-Parra, G; Thébaud, Bernard; Tamosiuniene, Rasa; Jain, Noopur; Navarro, Edwin F; Starcher, Barry C; Nicolls, Mark R; Rabinovitch, Marlene; Bland, Richard D.

Affiliation

Hilgendorff A; Department of Pediatrics, Stanford University, Stanford, California 94305-5162, USA.

Am J Physiol Lung Cell Mol Physiol ; 303(3): L215-27, 2012 Aug 01.

Article in En | MEDLINE | ID: mdl-22683569

Subject(s)

Elafin/physiology; Pancreatic Elastase/antagonists & inhibitors; Pneumonia/genetics; Pneumonia/prevention & control; Ventilator-Induced Lung Injury/genetics; Ventilator-Induced Lung Injury/prevention & control; Animals; Animals, Newborn; Apoptosis; Endothelium, Vascular/cytology; Endothelium, Vascular/metabolism; Female; Humans; Immunoblotting; Immunoenzyme Techniques; Macrophages/cytology; Macrophages/metabolism; Male; Mice; Mice, Transgenic; Monocytes/cytology; Monocytes/metabolism; Neutrophils/cytology; Neutrophils/metabolism; Oxygen/metabolism; Pancreatic Elastase/metabolism; Pulmonary Alveoli/pathology; RNA, Messenger/genetics; Real-Time Polymerase Chain Reaction; Respiration, Artificial; Respiratory Insufficiency/prevention & control; Reverse Transcriptase Polymerase Chain Reaction; Transforming Growth Factor beta/metabolism; Vascular Endothelial Growth Factor Receptor-2/genetics; Vascular Endothelial Growth Factor Receptor-2/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pneumonia / Pancreatic Elastase / Elafin / Ventilator-Induced Lung Injury Limits: Animals / Female / Humans / Male Language: En Journal: Am J Physiol Lung Cell Mol Physiol Journal subject: BIOLOGIA MOLECULAR / FISIOLOGIA Year: 2012 Type: Article Affiliation country: United States

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