The App-Runx1 region is critical for birth defects and electrocardiographic dysfunctions observed in a Down syndrome mouse model.

Raveau, Matthieu; Lignon, Jacques M; Nalesso, Valérie; Duchon, Arnaud; Groner, Yoram; Sharp, Andrew J; Dembele, Doulaye; Brault, Véronique; Hérault, Yann

Raveau, Matthieu; Lignon, Jacques M; Nalesso, Valérie; Duchon, Arnaud; Groner, Yoram; Sharp, Andrew J; Dembele, Doulaye; Brault, Véronique; Hérault, Yann.

Affiliation

Raveau M; Institut de Génétique et de Biologie Moléculaire et Cellulaire, Department of Translational Medicine and Neurogenetics, CNRS, INSERM, Université de Strasbourg, UMR7104, UMR964, Illkirch, France.

PLoS Genet ; 8(5): e1002724, 2012 May.

Article in En | MEDLINE | ID: mdl-22693452

Subject(s)

Amyloid beta-Protein Precursor/genetics; Core Binding Factor Alpha 2 Subunit/genetics; Down Syndrome; Gene Dosage; Heart Defects, Congenital; Animals; Congenital Abnormalities/genetics; Disease Models, Animal; Down Syndrome/genetics; Down Syndrome/metabolism; Electrocardiography; Gene Expression Regulation; Heart Block/physiopathology; Heart Defects, Congenital/genetics; Heart Defects, Congenital/physiopathology; Humans; Mice; Mice, Inbred C57BL; Mice, Transgenic; Phenotype

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Amyloid beta-Protein Precursor / Down Syndrome / Gene Dosage / Core Binding Factor Alpha 2 Subunit / Heart Defects, Congenital Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS Genet Journal subject: GENETICA Year: 2012 Type: Article Affiliation country: France

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