Prolonged early G(1) arrest by selective CDK4/CDK6 inhibition sensitizes myeloma cells to cytotoxic killing through cell cycle-coupled loss of IRF4.

Huang, Xiangao; Di Liberto, Maurizio; Jayabalan, David; Liang, Jun; Ely, Scott; Bretz, Jamieson; Shaffer, Arthur L; Louie, Tracey; Chen, Isan; Randolph, Sophia; Hahn, William C; Staudt, Louis M; Niesvizky, Ruben; Moore, Malcolm A S; Chen-Kiang, Selina

Huang, Xiangao; Di Liberto, Maurizio; Jayabalan, David; Liang, Jun; Ely, Scott; Bretz, Jamieson; Shaffer, Arthur L; Louie, Tracey; Chen, Isan; Randolph, Sophia; Hahn, William C; Staudt, Louis M; Niesvizky, Ruben; Moore, Malcolm A S; Chen-Kiang, Selina.

Affiliation

Huang X; Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA.

Blood ; 120(5): 1095-106, 2012 Aug 02.

Article in En | MEDLINE | ID: mdl-22718837

Subject(s)

Apoptosis/drug effects; G1 Phase Cell Cycle Checkpoints/drug effects; Interferon Regulatory Factors/genetics; Multiple Myeloma/drug therapy; Protein Kinase Inhibitors/pharmacology; Animals; Apoptosis/genetics; Boronic Acids/administration & dosage; Boronic Acids/pharmacology; Bortezomib; Cell Cycle/drug effects; Cell Cycle/genetics; Cell Line, Tumor; Cyclin-Dependent Kinase 4/antagonists & inhibitors; Cyclin-Dependent Kinase 6/antagonists & inhibitors; Cytotoxins/administration & dosage; Cytotoxins/pharmacology; Down-Regulation/drug effects; Down-Regulation/genetics; Drug Resistance, Neoplasm/drug effects; Drug Synergism; G1 Phase Cell Cycle Checkpoints/genetics; G1 Phase Cell Cycle Checkpoints/physiology; Gene Expression Regulation, Neoplastic/drug effects; Humans; Interferon Regulatory Factors/metabolism; Mice; Mice, Inbred NOD; Mice, SCID; Mice, Transgenic; Multiple Myeloma/genetics; Multiple Myeloma/pathology; Protein Kinase Inhibitors/administration & dosage; Pyrazines/administration & dosage; Pyrazines/pharmacology; Substrate Specificity; Time Factors; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Apoptosis / Protein Kinase Inhibitors / Interferon Regulatory Factors / G1 Phase Cell Cycle Checkpoints / Multiple Myeloma Type of study: Prognostic_studies Language: En Journal: Blood Year: 2012 Type: Article Affiliation country: United States

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