Overexpression of microRNA-1 impairs cardiac contractile function by damaging sarcomere assembly.

Ai, Jing; Zhang, Rong; Gao, Xu; Niu, Hui-Fang; Wang, Ning; Xu, Yi; Li, Yue; Ma, Ning; Sun, Li-Hua; Pan, Zhen-Wei; Li, Wei-Min; Yang, Bao-Feng

Ai, Jing; Zhang, Rong; Gao, Xu; Niu, Hui-Fang; Wang, Ning; Xu, Yi; Li, Yue; Ma, Ning; Sun, Li-Hua; Pan, Zhen-Wei; Li, Wei-Min; Yang, Bao-Feng.

Affiliation

Ai J; Department of Pharmacology , Harbin Medical University, No. 157 Baojian Road, Nangang District, Harbin, China. a.z.hrbmu@gmail.com

Cardiovasc Res ; 95(3): 385-93, 2012 Aug 01.

Article in En | MEDLINE | ID: mdl-22719074

Subject(s)

MicroRNAs/metabolism; Myocardial Contraction/genetics; Myocytes, Cardiac/metabolism; Sarcomeres/metabolism; 3' Untranslated Regions; Age Factors; Animals; Animals, Newborn; Binding Sites; Calmodulin/genetics; Calmodulin/metabolism; Cells, Cultured; Down-Regulation; Female; Gene Knockdown Techniques; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Microscopy, Electron; Myocytes, Cardiac/ultrastructure; Myosin Heavy Chains/genetics; Myosin-Light-Chain Kinase/genetics; Myosin-Light-Chain Kinase/metabolism; Promoter Regions, Genetic; RNA Interference; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Reverse Transcriptase Polymerase Chain Reaction; Sarcomeres/ultrastructure; Up-Regulation; Ventricular Function; Ventricular Myosins/genetics; Ventricular Remodeling

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Sarcomeres / Myocytes, Cardiac / MicroRNAs / Myocardial Contraction Type of study: Prognostic_studies Language: En Journal: Cardiovasc Res Year: 2012 Type: Article Affiliation country: China

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