Footprint of positive selection in Treponema pallidum subsp. pallidum genome sequences suggests adaptive microevolution of the syphilis pathogen.

Giacani, Lorenzo; Chattopadhyay, Sujay; Centurion-Lara, Arturo; Jeffrey, Brendan M; Le, Hoavan T; Molini, Barbara J; Lukehart, Sheila A; Sokurenko, Evgeni V; Rockey, Daniel D

Giacani, Lorenzo; Chattopadhyay, Sujay; Centurion-Lara, Arturo; Jeffrey, Brendan M; Le, Hoavan T; Molini, Barbara J; Lukehart, Sheila A; Sokurenko, Evgeni V; Rockey, Daniel D.

Affiliation

Giacani L; Department of Medicine, University of Washington, Seattle, WA, USA. giacal@u.washington.edu

PLoS Negl Trop Dis ; 6(6): e1698, 2012.

Article in En | MEDLINE | ID: mdl-22720110

Subject(s)

Evolution, Molecular; Selection, Genetic; Syphilis/microbiology; Treponema pallidum/classification; Treponema pallidum/genetics; Adaptation, Biological; Animals; Base Sequence; Computational Biology; DNA, Bacterial/genetics; Disease Models, Animal; Genome, Bacterial; Humans; Molecular Sequence Data; Polymorphism, Single Nucleotide; Rabbits; Sequence Analysis, DNA; Sequence Homology, Nucleic Acid

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Selection, Genetic / Treponema pallidum / Syphilis / Evolution, Molecular Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: PLoS Negl Trop Dis Journal subject: MEDICINA TROPICAL Year: 2012 Type: Article Affiliation country: United States

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