PGC7 binds histone H3K9me2 to protect against conversion of 5mC to 5hmC in early embryos.

Nakamura, Toshinobu; Liu, Yu-Jung; Nakashima, Hiroyuki; Umehara, Hiroki; Inoue, Kimiko; Matoba, Shogo; Tachibana, Makoto; Ogura, Atsuo; Shinkai, Yoichi; Nakano, Toru

Nakamura, Toshinobu; Liu, Yu-Jung; Nakashima, Hiroyuki; Umehara, Hiroki; Inoue, Kimiko; Matoba, Shogo; Tachibana, Makoto; Ogura, Atsuo; Shinkai, Yoichi; Nakano, Toru.

Affiliation

Nakamura T; Department of Pathology, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan. tnakamura@nagahama-i-bio.ac.jp

Nature ; 486(7403): 415-9, 2012 Jun 03.

Article in En | MEDLINE | ID: mdl-22722204

Subject(s)

5-Methylcytosine/metabolism; Cytosine/analogs & derivatives; Embryo, Mammalian/metabolism; Histones/chemistry; Histones/metabolism; Repressor Proteins/metabolism; Animals; Chromatin/chemistry; Chromatin/metabolism; Chromosomal Proteins, Non-Histone; Cytosine/metabolism; DNA Methylation; DNA-Binding Proteins/metabolism; Dioxygenases; Embryo, Mammalian/embryology; Embryonic Development; Female; Genomic Imprinting/genetics; Lysine/chemistry; Lysine/metabolism; Male; Methylation; Mice; Protein Binding/drug effects; Proto-Oncogene Proteins/metabolism; RNA, Long Noncoding; RNA, Untranslated/genetics; Spermatozoa/metabolism; ras-GRF1/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Repressor Proteins / Histones / Cytosine / 5-Methylcytosine / Embryo, Mammalian Limits: Animals Language: En Journal: Nature Year: 2012 Type: Article Affiliation country: Japan

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