Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor &#954;B (NF-&#954;B) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling.

Peng, Haiyan; Guerau-de-Arellano, Mireia; Mehta, Veela B; Yang, Yuhong; Huss, David J; Papenfuss, Tracey L; Lovett-Racke, Amy E; Racke, Michael K

Dimethyl fumarate inhibits dendritic cell maturation via nuclear factor κB (NF-κB) and extracellular signal-regulated kinase 1 and 2 (ERK1/2) and mitogen stress-activated kinase 1 (MSK1) signaling.

Peng, Haiyan; Guerau-de-Arellano, Mireia; Mehta, Veela B; Yang, Yuhong; Huss, David J; Papenfuss, Tracey L; Lovett-Racke, Amy E; Racke, Michael K.

Affiliation

Peng H; Neuroscience Graduate Studies Program, The Ohio State University, Columbus, Ohio 43210, USA.

J Biol Chem ; 287(33): 28017-26, 2012 Aug 10.

Article in En | MEDLINE | ID: mdl-22733812

Subject(s)

Dendritic Cells/immunology; Fumarates/pharmacology; Immunosuppressive Agents/pharmacology; MAP Kinase Signaling System/drug effects; Mitogen-Activated Protein Kinase 3/immunology; Ribosomal Protein S6 Kinases, 90-kDa/immunology; Transcription Factor RelA/immunology; Animals; B7-1 Antigen/biosynthesis; B7-1 Antigen/immunology; B7-2 Antigen/biosynthesis; B7-2 Antigen/immunology; Cell Differentiation/drug effects; Cell Differentiation/immunology; Cells, Cultured; Dendritic Cells/cytology; Dendritic Cells/metabolism; Dimethyl Fumarate; Histocompatibility Antigens Class II/biosynthesis; Histocompatibility Antigens Class II/immunology; Interleukin-12/immunology; Interleukin-12/metabolism; Interleukin-6/immunology; Interleukin-6/metabolism; MAP Kinase Signaling System/immunology; Mice; Mitogen-Activated Protein Kinase 3/metabolism; Phosphorylation/drug effects; Phosphorylation/immunology; Ribosomal Protein S6 Kinases, 90-kDa/metabolism; Th1 Cells/cytology; Th1 Cells/immunology; Th1 Cells/metabolism; Th17 Cells/cytology; Th17 Cells/immunology; Th17 Cells/metabolism; Transcription Factor RelA/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / MAP Kinase Signaling System / Ribosomal Protein S6 Kinases, 90-kDa / Mitogen-Activated Protein Kinase 3 / Transcription Factor RelA / Fumarates / Immunosuppressive Agents Limits: Animals Language: En Journal: J Biol Chem Year: 2012 Type: Article Affiliation country: United States

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