Type-specific response to neoadjuvant chemotherapy: ovarian high-grade serous carcinoma versus colorectal mucinous carcinoma.
J Obstet Gynaecol Can
; 34(7): 678-82, 2012 Jul.
Article
in En
| MEDLINE
| ID: mdl-22742488
ABSTRACT
BACKGROUND:
Ovarian carcinomas are currently managed as a single entity with no stratification for histological type. The foundation of treatment is a combination of surgery and chemotherapy. Women who are not candidates for up-front debulking surgery, either because of performance status or widespread disease, are often offered neoadjuvant chemotherapy in an effort to shrink their tumour and make resection possible. CASE A 76-year-old woman was treated with neoadjuvant platinum-based chemotherapy for advanced ovarian cancer. At interval debulking surgery, she was found to have a concurrent mucinous colorectal carcinoma that was essentially unaffected by her treatment.CONCLUSION:
This case serves as an in vivo demonstration of the greater resistance to platinum-based treatments of mucinous carcinomas than of the "typical" high-grade serous ovarian cancer.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Ovarian Neoplasms
/
Colonic Neoplasms
/
Drug Resistance, Neoplasm
/
Neoadjuvant Therapy
/
Neoplasms, Multiple Primary
/
Antineoplastic Agents
Limits:
Aged
/
Female
/
Humans
Language:
En
Journal:
J Obstet Gynaecol Can
Journal subject:
GINECOLOGIA
/
OBSTETRICIA
Year:
2012
Type:
Article