Glucose and blood pressure lowering effects of Pycnogenol® are inefficient to prevent prolongation of QT interval in experimental diabetic cardiomyopathy.

Jankyova, Stanislava; Kmecova, Jana; Cernecka, Hana; Mesarosova, Lucia; Musil, Peter; Brnoliakova, Zuzana; Kyselovic, Jan; Babal, Pavel; Klimas, Jan

Jankyova, Stanislava; Kmecova, Jana; Cernecka, Hana; Mesarosova, Lucia; Musil, Peter; Brnoliakova, Zuzana; Kyselovic, Jan; Babal, Pavel; Klimas, Jan.

Affiliation

Jankyova S; Department of Pharmacology and Toxicology, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic. jankyova@fpharm.uniba.sk

Pathol Res Pract ; 208(8): 452-7, 2012 Aug 15.

Article in En | MEDLINE | ID: mdl-22749577

Subject(s)

Antioxidants/pharmacology; Blood Glucose/drug effects; Blood Pressure/drug effects; Diabetic Cardiomyopathies/drug therapy; Flavonoids/pharmacology; Hypoglycemic Agents/pharmacology; Long QT Syndrome/drug therapy; Animals; Diabetes Mellitus, Experimental/blood; Diabetes Mellitus, Experimental/complications; Diabetes Mellitus, Experimental/drug therapy; Diabetes Mellitus, Experimental/physiopathology; Dose-Response Relationship, Drug; Heart Ventricles/drug effects; Heart Ventricles/pathology; Hyperglycemia/drug therapy; Hypertrophy, Left Ventricular/pathology; Hypertrophy, Left Ventricular/prevention & control; Long QT Syndrome/etiology; Long QT Syndrome/physiopathology; Male; Myocytes, Cardiac/drug effects; Myocytes, Cardiac/pathology; Organ Size/drug effects; Plant Extracts; Rats; Rats, Wistar

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Flavonoids / Blood Glucose / Blood Pressure / Long QT Syndrome / Diabetic Cardiomyopathies / Hypoglycemic Agents / Antioxidants Type of study: Etiology_studies Limits: Animals Language: En Journal: Pathol Res Pract Year: 2012 Type: Article

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