Prolyl endopeptidase-deficient mice have reduced synaptic spine density in the CA1 region of the hippocampus, impaired LTP, and spatial learning and memory.

D'Agostino, Giuseppe; Kim, Jung Dae; Liu, Zhong-Wu; Jeong, Jin Kwon; Suyama, Shigetomo; Calignano, Antonio; Gao, Xiao-Bing; Schwartz, Michael; Diano, Sabrina

D'Agostino, Giuseppe; Kim, Jung Dae; Liu, Zhong-Wu; Jeong, Jin Kwon; Suyama, Shigetomo; Calignano, Antonio; Gao, Xiao-Bing; Schwartz, Michael; Diano, Sabrina.

Affiliation

D'Agostino G; Department of Obstetrics, Gynecology and Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06520, USA.

Cereb Cortex ; 23(8): 2007-14, 2013 Aug.

Article in En | MEDLINE | ID: mdl-22767632

Subject(s)

CA1 Region, Hippocampal/ultrastructure; Dendritic Spines/ultrastructure; Long-Term Potentiation/physiology; Maze Learning/physiology; Memory/physiology; Serine Endopeptidases/physiology; Synapses/ultrastructure; Animals; CA1 Region, Hippocampal/physiology; Gene Knockdown Techniques; Male; Mice; Prolyl Oligopeptidases; Serine Endopeptidases/genetics

Key words

CA1; hippocampus; long-term potentiation; prolyl endopeptidase; synaptic spines

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Synapses / Serine Endopeptidases / Long-Term Potentiation / Maze Learning / Dendritic Spines / CA1 Region, Hippocampal / Memory Limits: Animals Language: En Journal: Cereb Cortex Journal subject: CEREBRO Year: 2013 Type: Article Affiliation country: United States

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