Intrathecal injection of spironolactone attenuates radicular pain by inhibition of spinal microglia activation in a rat model.

Sun, Yu-e; Peng, Liangyu; Sun, Xiaofeng; Bo, Jinhua; Yang, Dong; Zheng, Yaguo; Liu, Chenglong; Zhu, Beibei; Ma, Zhengliang; Gu, Xiaoping

Sun, Yu-e; Peng, Liangyu; Sun, Xiaofeng; Bo, Jinhua; Yang, Dong; Zheng, Yaguo; Liu, Chenglong; Zhu, Beibei; Ma, Zhengliang; Gu, Xiaoping.

Affiliation

Sun YE; Department of Anaesthesiology, Affiliated Drum-Tower Hospital of Medical College of Nanjing University, Nanjing, Jiangsu province, China.

PLoS One ; 7(6): e39897, 2012.

Article in En | MEDLINE | ID: mdl-22768159

Subject(s)

Ganglia, Spinal/pathology; Microglia/pathology; Pain/drug therapy; Spinal Cord/pathology; Spironolactone/administration & dosage; Spironolactone/therapeutic use; Animals; Blotting, Western; Cytokines/biosynthesis; Disease Models, Animal; Ganglia, Spinal/drug effects; Immunohistochemistry; Inflammation Mediators/metabolism; Injections, Spinal; Male; Microglia/drug effects; Microglia/metabolism; Pain/complications; Pain/pathology; Phosphorylation/drug effects; Posterior Horn Cells/drug effects; Posterior Horn Cells/metabolism; Posterior Horn Cells/pathology; Radiculopathy/complications; Radiculopathy/drug therapy; Rats; Rats, Sprague-Dawley; Receptors, N-Methyl-D-Aspartate/metabolism; Spinal Cord/drug effects; Spinal Cord/metabolism; Spironolactone/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Pain / Spinal Cord / Spironolactone / Microglia / Ganglia, Spinal Type of study: Prognostic_studies Limits: Animals Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Type: Article Affiliation country: China

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