Necdin, a p53 target gene, regulates the quiescence and response to genotoxic stress of hematopoietic stem/progenitor cells.

Asai, Takashi; Liu, Yan; Di Giandomenico, Silvana; Bae, Narae; Ndiaye-Lobry, Delphine; Deblasio, Anthony; Menendez, Silvia; Antipin, Yevgeniy; Reva, Boris; Wevrick, Rachel; Nimer, Stephen D

Asai, Takashi; Liu, Yan; Di Giandomenico, Silvana; Bae, Narae; Ndiaye-Lobry, Delphine; Deblasio, Anthony; Menendez, Silvia; Antipin, Yevgeniy; Reva, Boris; Wevrick, Rachel; Nimer, Stephen D.

Affiliation

Asai T; Molecular Pharmacology and Chemistry Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, USA.

Blood ; 120(8): 1601-12, 2012 Aug 23.

Article in En | MEDLINE | ID: mdl-22776820

Subject(s)

DNA Damage; Hematopoiesis; Hematopoietic Stem Cells/cytology; Nerve Tissue Proteins/genetics; Nerve Tissue Proteins/metabolism; Nuclear Proteins/genetics; Nuclear Proteins/metabolism; Tumor Suppressor Protein p53/metabolism; Animals; Apoptosis; Cell Proliferation; Cells, Cultured; Drug Therapy; Gene Deletion; Genes, p53; Hematopoietic Stem Cells/drug effects; Hematopoietic Stem Cells/metabolism; Hematopoietic Stem Cells/radiation effects; Liver/cytology; Liver/embryology; Mice; Mice, Inbred C57BL

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: DNA Damage / Hematopoietic Stem Cells / Nuclear Proteins / Tumor Suppressor Protein p53 / Hematopoiesis / Nerve Tissue Proteins Limits: Animals Language: En Journal: Blood Year: 2012 Type: Article Affiliation country: United States

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