The functional interaction between Acyl-CoA synthetase 4, 5-lipooxygenase and cyclooxygenase-2 controls tumor growth: a novel therapeutic target.

Orlando, Ulises D; Garona, Juan; Ripoll, Giselle V; Maloberti, Paula M; Solano, Ángela R; Avagnina, Alejandra; Gomez, Daniel E; Alonso, Daniel F; Podestá, Ernesto J

Orlando, Ulises D; Garona, Juan; Ripoll, Giselle V; Maloberti, Paula M; Solano, Ángela R; Avagnina, Alejandra; Gomez, Daniel E; Alonso, Daniel F; Podestá, Ernesto J.

Affiliation

Orlando UD; Instituto de Investigaciones Biomédicas, Department of Human Biochemistry, School of Medicine, University of Buenos Aires, Buenos Aires, Argentina.

PLoS One ; 7(7): e40794, 2012.

Article in En | MEDLINE | ID: mdl-22808264

Subject(s)

Arachidonate 5-Lipoxygenase/metabolism; Breast Neoplasms/enzymology; Breast Neoplasms/pathology; Coenzyme A Ligases/metabolism; Cyclooxygenase 2/metabolism; Molecular Targeted Therapy; Analysis of Variance; Animals; Cell Movement/drug effects; Cell Proliferation/drug effects; Coenzyme A Ligases/antagonists & inhibitors; Enzyme Inhibitors/administration & dosage; Enzyme Inhibitors/pharmacology; Estrogen Receptor alpha/metabolism; Female; Humans; Immunohistochemistry; Injections, Intraperitoneal; MCF-7 Cells; Mice; Receptors, Progesterone/metabolism; Tetracycline/pharmacology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Arachidonate 5-Lipoxygenase / Breast Neoplasms / Coenzyme A Ligases / Cyclooxygenase 2 / Molecular Targeted Therapy Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: PLoS One Journal subject: CIENCIA / MEDICINA Year: 2012 Type: Article Affiliation country: Argentina

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