Endogenous concentrations of ouabain act as a cofactor to stimulate fluid secretion and cyst growth of in vitro ADPKD models via cAMP and EGFR-Src-MEK pathways.

Jansson, Kyle; Nguyen, Anh-Nguyet T; Magenheimer, Brenda S; Reif, Gail A; Aramadhaka, Lavakumar Reddy; Bello-Reuss, Elsa; Wallace, Darren P; Calvet, James P; Blanco, Gustavo

Jansson, Kyle; Nguyen, Anh-Nguyet T; Magenheimer, Brenda S; Reif, Gail A; Aramadhaka, Lavakumar Reddy; Bello-Reuss, Elsa; Wallace, Darren P; Calvet, James P; Blanco, Gustavo.

Affiliation

Jansson K; Dept. of Molecular and Integrative Physiology, 3901 Rainbow Blvd., Kansas City, KS 66160, USA.

Am J Physiol Renal Physiol ; 303(7): F982-90, 2012 Oct.

Article in En | MEDLINE | ID: mdl-22859406

Subject(s)

Cyclic AMP/metabolism; Cysts/metabolism; ErbB Receptors/metabolism; Kidney/metabolism; Ouabain/metabolism; Polycystic Kidney, Autosomal Dominant/metabolism; Signal Transduction/physiology; Animals; Cell Proliferation/drug effects; Cells, Cultured; Colforsin/pharmacology; Epithelial Cells/drug effects; Epithelial Cells/metabolism; Humans; Kidney/cytology; Kidney/drug effects; Mice; Signal Transduction/drug effects

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Ouabain / Signal Transduction / Polycystic Kidney, Autosomal Dominant / Cyclic AMP / Cysts / ErbB Receptors / Kidney Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: Am J Physiol Renal Physiol Journal subject: FISIOLOGIA / NEFROLOGIA Year: 2012 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google