Structure-activity relationships in the development of allosteric hepatitis C virus RNA-dependent RNA polymerase inhibitors: ten years of research.

Haudecoeur, Romain; Peuchmaur, Marine; Ahmed-Belkacem, Abdelhakim; Pawlotsky, Jean-Michel; Boumendjel, Ahcène

Haudecoeur, Romain; Peuchmaur, Marine; Ahmed-Belkacem, Abdelhakim; Pawlotsky, Jean-Michel; Boumendjel, Ahcène.

Affiliation

Haudecoeur R; Département de Pharmacochimie Moléculaire, Université de Grenoble/CNRS, UMR 5063, BP 53, 38041, Grenoble Cedex 9, France.

Med Res Rev ; 33(5): 934-84, 2013 Sep.

Article in En | MEDLINE | ID: mdl-22893620

Subject(s)

Enzyme Inhibitors/pharmacology; Hepacivirus/enzymology; RNA-Dependent RNA Polymerase/antagonists & inhibitors; Allosteric Regulation/drug effects; Animals; Binding Sites; Enzyme Inhibitors/chemistry; Hepacivirus/drug effects; Humans; RNA-Dependent RNA Polymerase/metabolism; Structure-Activity Relationship

Key words

RdRp; allosteric inhibitors; hepatitis C; polymerase; structure-activity relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: RNA-Dependent RNA Polymerase / Hepacivirus / Enzyme Inhibitors Limits: Animals / Humans Language: En Journal: Med Res Rev Year: 2013 Type: Article Affiliation country: France

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