MyD88 drives the IFN-ß response to Lactobacillus acidophilus in dendritic cells through a mechanism involving IRF1, IRF3, and IRF7.

Weiss, Gudrun; Maaetoft-Udsen, Kristina; Stifter, Sebastian A; Hertzog, Paul; Goriely, Stanislas; Thomsen, Allan R; Paludan, Søren R; Frøkiær, Hanne

Weiss, Gudrun; Maaetoft-Udsen, Kristina; Stifter, Sebastian A; Hertzog, Paul; Goriely, Stanislas; Thomsen, Allan R; Paludan, Søren R; Frøkiær, Hanne.

Affiliation

Weiss G; Department of Basic Sciences and Environment, Molecular Immunology, Faculty of Life Sciences, University of Copenhagen, 1871 Frederiksberg, Denmark. gudrun.weiss@imperial.ac.uk

J Immunol ; 189(6): 2860-8, 2012 Sep 15.

Article in En | MEDLINE | ID: mdl-22896628

Subject(s)

Dendritic Cells/immunology; Dendritic Cells/microbiology; Interferon Regulatory Factor-1/physiology; Interferon Regulatory Factor-3/physiology; Interferon Regulatory Factor-7/physiology; Interferon-beta/metabolism; Lactobacillus acidophilus/immunology; Myeloid Differentiation Factor 88/physiology; Animals; Cells, Cultured; Dendritic Cells/metabolism; Endosomes/immunology; Endosomes/metabolism; Endosomes/microbiology; Interferon Regulatory Factor-1/deficiency; Interferon Regulatory Factor-3/antagonists & inhibitors; Interferon Regulatory Factor-3/deficiency; Interferon Regulatory Factor-7/antagonists & inhibitors; Interferon Regulatory Factor-7/deficiency; Mice; Mice, Inbred C57BL; Mice, Knockout; Myeloid Differentiation Factor 88/deficiency; Phagosomes/immunology; Phagosomes/metabolism; Protein Processing, Post-Translational/immunology; Signal Transduction/genetics; Signal Transduction/immunology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Dendritic Cells / Interferon-beta / Interferon Regulatory Factor-1 / Interferon Regulatory Factor-3 / Interferon Regulatory Factor-7 / Myeloid Differentiation Factor 88 / Lactobacillus acidophilus Limits: Animals Language: En Journal: J Immunol Year: 2012 Type: Article Affiliation country: Denmark

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