Histone acetylation and DNA demethylation of T cells result in an anaplastic large cell lymphoma-like phenotype.

Joosten, Maria; Seitz, Volkhard; Zimmermann, Karin; Sommerfeld, Anke; Berg, Erika; Lenze, Dido; Leser, Ulf; Stein, Harald; Hummel, Michael

Joosten, Maria; Seitz, Volkhard; Zimmermann, Karin; Sommerfeld, Anke; Berg, Erika; Lenze, Dido; Leser, Ulf; Stein, Harald; Hummel, Michael.

Affiliation

Joosten M; Institute of Pathology, Charité-Universitätsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany.

Haematologica ; 98(2): 247-54, 2013 Feb.

Article in En | MEDLINE | ID: mdl-22899583

Subject(s)

DNA Methylation; Histones/metabolism; Lymphoma, Large-Cell, Anaplastic/genetics; Lymphoma, Large-Cell, Anaplastic/metabolism; Phenotype; T-Lymphocytes/metabolism; T-Lymphocytes/pathology; Azacitidine/analogs & derivatives; Azacitidine/pharmacology; B-Lymphocytes/drug effects; B-Lymphocytes/metabolism; B-Lymphocytes/pathology; Cell Line, Tumor; Cluster Analysis; Decitabine; Epigenesis, Genetic/drug effects; Gene Expression Profiling; Gene Expression Regulation, Neoplastic/drug effects; Gene Silencing; Histones/genetics; Humans; Hydroxamic Acids/pharmacology; Inhibitor of Differentiation Protein 2/genetics; Inhibitor of Differentiation Protein 2/metabolism; Lymphoma, Large-Cell, Anaplastic/diagnosis; Promoter Regions, Genetic; T-Lymphocytes/drug effects; Transcription Factors/genetics; Transcription Factors/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Phenotype / Histones / T-Lymphocytes / Lymphoma, Large-Cell, Anaplastic / DNA Methylation Type of study: Diagnostic_studies Limits: Humans Language: En Journal: Haematologica Year: 2013 Type: Article Affiliation country: Germany

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