Expansion and de novo occurrence of Y chromosome microdeletions occurring via natural vertical transmission in northeastern China.
J Int Med Res
; 40(3): 1182-91, 2012.
Article
in En
| MEDLINE
| ID: mdl-22906293
ABSTRACT
OBJECTIVE:
To determine characteristics of classical and partial deletions of the Y chromosome azoospermia factor (AZF) region transmitted from father to son by natural fertilization.METHODS:
Patients from northeastern China with primary male infertility (n = 10) and their fathers were investigated. Healthy fertile men and women were recruited as positive and negative controls, respectively. The Y chromosome microdeletions were detected by polymerase chain reaction. Serum concentrations of reproductive hormones were determined by electrochemiluminescence immunoassay and enzyme-linked immunosorbent assay.RESULTS:
Expansions of microdeletions were observed in seven fatherson pairs; de novo microdeletions were found in the remaining three fatherson pairs. The Y chromosome microdeletions were larger in sons than in their fathers. Patients with infertility had significantly higher levels of follicle stimulating hormone and lower levels of inhibin B than fertile men.CONCLUSIONS:
The Y chromosome microdeletions were transmitted from father to son via natural transmission. These microdeletions may expand during transmission or arise de novo, possibly resulting in reduced fertility.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
Chromosome Deletion
/
Gene Transfer Techniques
/
Chromosomes, Human, Y
Type of study:
Observational_studies
Limits:
Adult
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
J Int Med Res
Year:
2012
Type:
Article
Affiliation country:
China