A dense poly(ethylene glycol) coating improves penetration of large polymeric nanoparticles within brain tissue.

Nance, Elizabeth A; Woodworth, Graeme F; Sailor, Kurt A; Shih, Ting-Yu; Xu, Qingguo; Swaminathan, Ganesh; Xiang, Dennis; Eberhart, Charles; Hanes, Justin

Nance, Elizabeth A; Woodworth, Graeme F; Sailor, Kurt A; Shih, Ting-Yu; Xu, Qingguo; Swaminathan, Ganesh; Xiang, Dennis; Eberhart, Charles; Hanes, Justin.

Affiliation

Nance EA; Center for Nanomedicine at the Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.

Sci Transl Med ; 4(149): 149ra119, 2012 Aug 29.

Article in En | MEDLINE | ID: mdl-22932224

Subject(s)

Brain/metabolism; Coated Materials, Biocompatible; Drug Carriers; Nanoparticles; Paclitaxel/metabolism; Polyethylene Glycols/chemistry; Polystyrenes/metabolism; Animals; Blood-Brain Barrier/metabolism; Chemistry, Pharmaceutical; Diffusion; Female; Humans; Mice; Microscopy, Confocal; Microscopy, Fluorescence; Microscopy, Video; Nanotechnology; Paclitaxel/chemistry; Particle Size; Permeability; Polystyrenes/administration & dosage; Polystyrenes/chemistry; Rats; Rats, Sprague-Dawley; Surface Properties; Time Factors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Polyethylene Glycols / Polystyrenes / Brain / Drug Carriers / Paclitaxel / Coated Materials, Biocompatible / Nanoparticles Limits: Animals / Female / Humans Language: En Journal: Sci Transl Med Journal subject: CIENCIA / MEDICINA Year: 2012 Type: Article Affiliation country: United States

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