Addition of interferon-&#945; to the p53-SLP® vaccine results in increased production of interferon-Î³ in vaccinated colorectal cancer patients: a phase I/II clinical trial.

Zeestraten, Eliane C M; Speetjens, Frank M; Welters, Marij J P; Saadatmand, Sepideh; Stynenbosch, Linda F M; Jongen, Rogier; Kapiteijn, Ellen; Gelderblom, Hans; Nijman, Hans W; Valentijn, A Rob P M; Oostendorp, Jaap; Fathers, Lorraine M; Drijfhout, Jan W; van de Velde, Cornelis J H; Kuppen, Peter J K; van der Burg, Sjoerd H; Melief, Cornelis J M

Addition of interferon-α to the p53-SLP® vaccine results in increased production of interferon-Î³ in vaccinated colorectal cancer patients: a phase I/II clinical trial.

Zeestraten, Eliane C M; Speetjens, Frank M; Welters, Marij J P; Saadatmand, Sepideh; Stynenbosch, Linda F M; Jongen, Rogier; Kapiteijn, Ellen; Gelderblom, Hans; Nijman, Hans W; Valentijn, A Rob P M; Oostendorp, Jaap; Fathers, Lorraine M; Drijfhout, Jan W; van de Velde, Cornelis J H; Kuppen, Peter J K; van der Burg, Sjoerd H; Melief, Cornelis J M.

Affiliation

Zeestraten EC; Department of Surgery, Leiden University Medical Center, Leiden, The Netherlands.

Int J Cancer ; 132(7): 1581-91, 2013 Apr 01.

Article in En | MEDLINE | ID: mdl-22948952

Subject(s)

Antiviral Agents/therapeutic use; Cancer Vaccines/therapeutic use; Colorectal Neoplasms/therapy; Interferon-alpha/therapeutic use; Interferon-gamma/metabolism; Liver Neoplasms/therapy; Peptide Fragments/therapeutic use; Polyethylene Glycols/therapeutic use; Tumor Suppressor Protein p53/metabolism; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cohort Studies; Colorectal Neoplasms/immunology; Colorectal Neoplasms/pathology; Female; Follow-Up Studies; Humans; Leukocytes, Mononuclear/cytology; Leukocytes, Mononuclear/drug effects; Leukocytes, Mononuclear/metabolism; Liver Neoplasms/immunology; Liver Neoplasms/secondary; Male; Middle Aged; Prognosis; Recombinant Proteins/therapeutic use; Tumor Suppressor Protein p53/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Antiviral Agents / Peptide Fragments / Polyethylene Glycols / Colorectal Neoplasms / Tumor Suppressor Protein p53 / Interferon-gamma / Interferon-alpha / Cancer Vaccines / Liver Neoplasms Type of study: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Int J Cancer Year: 2013 Type: Article Affiliation country: Netherlands

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