Myoblasts derived from normal hESCs and dystrophic hiPSCs efficiently fuse with existing muscle fibers following transplantation.

Goudenege, Sébastien; Lebel, Carl; Huot, Nicolas B; Dufour, Christine; Fujii, Isao; Gekas, Jean; Rousseau, Joël; Tremblay, Jacques P

Goudenege, Sébastien; Lebel, Carl; Huot, Nicolas B; Dufour, Christine; Fujii, Isao; Gekas, Jean; Rousseau, Joël; Tremblay, Jacques P.

Affiliation

Goudenege S; Unité de recherche de recherche en Génétique Humaine, Centre de recherche de CHUL, CHUQ, Faculté de médecine, Université Laval, Québec, Québec, Canada.

Mol Ther ; 20(11): 2153-67, 2012 Nov.

Article in En | MEDLINE | ID: mdl-22990676

Subject(s)

Embryonic Stem Cells/physiology; Induced Pluripotent Stem Cells/physiology; Muscle, Skeletal/physiopathology; Muscular Dystrophy, Duchenne/therapy; Myoblasts, Skeletal/transplantation; Animals; Cell Differentiation; Cell Fusion; Cell Shape; Cells, Cultured; Culture Media; Dystrophin/metabolism; Embryonic Stem Cells/transplantation; Humans; Induced Pluripotent Stem Cells/transplantation; Lamin Type A/metabolism; Mice; Mice, Inbred mdx; Muscle, Skeletal/metabolism; Muscle, Skeletal/pathology; Muscular Dystrophy, Duchenne/pathology; Muscular Dystrophy, Duchenne/physiopathology; MyoD Protein/genetics; MyoD Protein/metabolism; Myoblasts, Skeletal/metabolism; Myoblasts, Skeletal/pathology; Regeneration; Spectrin/metabolism; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Muscle, Skeletal / Muscular Dystrophy, Duchenne / Myoblasts, Skeletal / Embryonic Stem Cells / Induced Pluripotent Stem Cells Type of study: Guideline Limits: Animals / Humans Language: En Journal: Mol Ther Journal subject: BIOLOGIA MOLECULAR / TERAPEUTICA Year: 2012 Type: Article Affiliation country: Canada

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