Phlorofucofuroeckol A suppresses expression of inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines via inhibition of nuclear factor-&#954;B, c-Jun NH2-terminal kinases, and Akt in microglial cells.

Kim, A-Reum; Lee, Min-Sup; Choi, Ji-Woong; Utsuki, Tadanobu; Kim, Jae-Il; Jang, Byeong-Churl; Kim, Hyeung-Rak

Phlorofucofuroeckol A suppresses expression of inducible nitric oxide synthase, cyclooxygenase-2, and pro-inflammatory cytokines via inhibition of nuclear factor-κB, c-Jun NH2-terminal kinases, and Akt in microglial cells.

Kim, A-Reum; Lee, Min-Sup; Choi, Ji-Woong; Utsuki, Tadanobu; Kim, Jae-Il; Jang, Byeong-Churl; Kim, Hyeung-Rak.

Affiliation

Kim AR; Molecular Nutrition Laboratory, Department of Food Science and Nutrition, Pukyong National University, 599-1 Daeyeon-3-dong, Nam-gu, Busan 608-737, South Korea.

Inflammation ; 36(2): 259-71, 2013 Apr.

Article in En | MEDLINE | ID: mdl-22993079

Subject(s)

Benzofurans/pharmacology; Dioxins/pharmacology; JNK Mitogen-Activated Protein Kinases/antagonists & inhibitors; Microglia/metabolism; NF-kappa B/antagonists & inhibitors; Proto-Oncogene Proteins c-akt/antagonists & inhibitors; Animals; Cyclooxygenase 2/biosynthesis; Cytokines/biosynthesis; Dinoprostone/biosynthesis; Extracellular Signal-Regulated MAP Kinases/metabolism; I-kappa B Proteins/drug effects; I-kappa B Proteins/metabolism; MAP Kinase Signaling System/drug effects; Mice; Microglia/drug effects; NF-KappaB Inhibitor alpha; Nitric Oxide/biosynthesis; Nitric Oxide Synthase Type II/biosynthesis; Phaeophyceae; Plant Extracts/pharmacology; Protein Transport/drug effects; Reactive Oxygen Species; Transcription Factor RelA/drug effects; Transcription Factor RelA/metabolism; p38 Mitogen-Activated Protein Kinases/antagonists & inhibitors

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Benzofurans / NF-kappa B / Microglia / JNK Mitogen-Activated Protein Kinases / Dioxins / Proto-Oncogene Proteins c-akt Limits: Animals Language: En Journal: Inflammation Year: 2013 Type: Article Affiliation country: South Korea

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