Enhanced phosphoinositide 3-kinase(p110&#945;) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.

Ritchie, R H; Love, J E; Huynh, K; Bernardo, B C; Henstridge, D C; Kiriazis, H; Tham, Y K; Sapra, G; Qin, C; Cemerlang, N; Boey, E J H; Jandeleit-Dahm, K; Du, X-J; McMullen, J R

Enhanced phosphoinositide 3-kinase(p110α) activity prevents diabetes-induced cardiomyopathy and superoxide generation in a mouse model of diabetes.

Ritchie, R H; Love, J E; Huynh, K; Bernardo, B C; Henstridge, D C; Kiriazis, H; Tham, Y K; Sapra, G; Qin, C; Cemerlang, N; Boey, E J H; Jandeleit-Dahm, K; Du, X-J; McMullen, J R.

Affiliation

Ritchie RH; Baker IDI Heart and Diabetes Institute, St Kilda Rd Central, Melbourne, VIC 8008, Australia. rebecca.ritchie@bakeridi.edu.au

Diabetologia ; 55(12): 3369-81, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23001375

Subject(s)

Class I Phosphatidylinositol 3-Kinases/metabolism; Diabetes Mellitus, Experimental/metabolism; Diabetes Mellitus, Type 1/metabolism; Diabetic Cardiomyopathies/metabolism; Diabetic Cardiomyopathies/prevention & control; Superoxides/metabolism; Animals; Blotting, Northern; Gene Expression Regulation; Male; Mice; Mice, Inbred C57BL; Mice, Transgenic; Oxidative Stress

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Superoxides / Diabetes Mellitus, Experimental / Diabetes Mellitus, Type 1 / Diabetic Cardiomyopathies / Class I Phosphatidylinositol 3-Kinases Limits: Animals Language: En Journal: Diabetologia Year: 2012 Type: Article Affiliation country: Australia

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