Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.

McPherson, Craig J; Aschenbrenner, Lisa M; Lacey, Brian M; Fahnoe, Kelly C; Lemmon, Margaret M; Finegan, Steven M; Tadakamalla, Baswanth; O'Donnell, John P; Mueller, John P; Tomaras, Andrew P

McPherson, Craig J; Aschenbrenner, Lisa M; Lacey, Brian M; Fahnoe, Kelly C; Lemmon, Margaret M; Finegan, Steven M; Tadakamalla, Baswanth; O'Donnell, John P; Mueller, John P; Tomaras, Andrew P.

Affiliation

McPherson CJ; Antibacterials Research Unit, Pfizer Worldwide Research & Development, Groton, CT, USA.

Antimicrob Agents Chemother ; 56(12): 6334-42, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23027195

Subject(s)

Anti-Bacterial Agents/pharmacology; Drug Resistance, Bacterial/physiology; Gram-Negative Bacteria/drug effects; Gram-Negative Bacteria/genetics; beta-Lactams/pharmacology; Animals; Bacterial Outer Membrane Proteins/genetics; Bacterial Outer Membrane Proteins/metabolism; Blotting, Western; Cloning, Molecular; Cross Infection/microbiology; Drug Resistance, Bacterial/genetics; Drug Resistance, Multiple, Bacterial/genetics; Escherichia coli/genetics; Gene Library; Mice; Porins/genetics; Pseudomonas aeruginosa/drug effects; Pseudomonas aeruginosa/genetics; Sepsis/drug therapy; Sepsis/microbiology; Siderophores; beta-Lactamases/biosynthesis; beta-Lactamases/genetics

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance, Bacterial / Beta-Lactams / Gram-Negative Bacteria / Anti-Bacterial Agents Limits: Animals Language: En Journal: Antimicrob Agents Chemother Year: 2012 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google