The combined effect of persistent organic pollutants in the serum POP mixture in Greenlandic Inuit: xenoestrogenic, xenoandrogenic and dioxin-like transactivities.
Biomarkers
; 17(8): 692-705, 2012 Dec.
Article
in En
| MEDLINE
| ID: mdl-23030067
ABSTRACT
Greenlandic Inuit have high body burden of persistent organic pollutants (POPs). We analyzed the combined effect of the actual lipophilic serum POP mixture on estrogen-, androgen- and aryl hydrocarbon-receptor functions as effect biomarkers, and the associations between the effect biomarkers and serum POPs, and lifestyle characteristics. The serum POPs were extracted from 232 Inuit from Ittoqqortoormiit, Narsaq and Qeqertarsuaq. The POP-related receptor transactivities correlated negatively to the POP levels and were associated to the lifestyle characteristics. The POP-related receptor transactivities can be used as effect biomarkers. The serum POPs have hormone disruptive potentials.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Inuit
/
Receptors, Androgen
/
Receptors, Estrogen
/
Receptors, Aryl Hydrocarbon
/
Environmental Pollutants
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Country/Region as subject:
America do norte
/
Europa
Language:
En
Journal:
Biomarkers
Journal subject:
BIOQUIMICA
Year:
2012
Type:
Article
Affiliation country:
Denmark