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Genomic analysis of two novel human enterovirus C genotypes found in respiratory samples from Peru.
Tokarz, Rafal; Hirschberg, David L; Sameroff, Stephen; Haq, Saddef; Luna, Giannina; Bennett, Andrew J; Silva, Maria; Leguia, Mariana; Kasper, Matthew; Bausch, Daniel G; Lipkin, W Ian.
Affiliation
  • Tokarz R; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Hirschberg DL; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Sameroff S; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Haq S; Center for Infection and Immunity, Mailman School of Public Health, Columbia University, New York, NY, USA.
  • Luna G; US Naval Medical Research Unit 6, Lima, Peru.
  • Bennett AJ; US Naval Medical Research Unit 6, Lima, Peru.
  • Silva M; Tulane School of Public Health and Tropical Medicine, New Orleans, LA, USA.
  • Leguia M; US Naval Medical Research Unit 6, Lima, Peru.
  • Kasper M; US Naval Medical Research Unit 6, Lima, Peru.
  • Bausch DG; US Naval Medical Research Unit 6, Lima, Peru.
  • Lipkin WI; US Naval Medical Research Unit 6, Lima, Peru.
J Gen Virol ; 94(Pt 1): 120-127, 2013 Jan.
Article in En | MEDLINE | ID: mdl-23034595
ABSTRACT
We report the discovery of two enteroviruses detected in nasopharyngeal samples obtained from subjects with respiratory disease in Peru. Phylogenetic analysis indicated that both viruses belong to a clade within the species Human enterovirus C, which includes the recently characterized human enteroviruses 109 and 104. Members of this clade have undergone significant genomic rearrangement, as indicated by deletions in the hypervariable region of the 5' UTR and the VP1 protein, as well as recombination within the non-structural genes. Our findings and review of published sequences suggests that several novel human enterovirus C serotypes are currently circulating worldwide.
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory System / Respiratory Tract Diseases / Genome, Viral / Enterovirus C, Human / Enterovirus Infections Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Humans Country/Region as subject: America do sul / Peru Language: En Journal: J Gen Virol Year: 2013 Type: Article Affiliation country: United States
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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Respiratory System / Respiratory Tract Diseases / Genome, Viral / Enterovirus C, Human / Enterovirus Infections Type of study: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Limits: Humans Country/Region as subject: America do sul / Peru Language: En Journal: J Gen Virol Year: 2013 Type: Article Affiliation country: United States