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Surveillance of the efficacy of artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum among children under five in Togo, 2005-2009.
Dorkenoo, Monique A; Barrette, Amy; Agbo, Yao M; Bogreau, Hervé; Kutoati, Séenam; Sodahlon, Yao K; Morgah, Kodjo.
Affiliation
  • Dorkenoo MA; Faculté Mixte de Médecine et de Pharmacie, Université de Lomé, Lomé, BP1515, Togo. monicadork@yahoo.fr
Malar J ; 11: 338, 2012 Oct 08.
Article in En | MEDLINE | ID: mdl-23043495
BACKGROUND: Malaria remains a major public health problem in Togo. The national malaria control programme in Togo changed the anti-malarial treatment policy from monotherapy to artemisinin combination therapy in 2004. This study reports the results of therapeutic efficacy studies conducted on artemether-lumefantrine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Togo, between 2005 and 2009. METHODS: Children between 6 and 59 months of age, who were symptomatically infected with P. falciparum, were treated with either artemether-lumefantrine or artesunate-amodiaquine. The primary end-point was the 28-day cure rate, PCR-corrected for reinfection and recrudescence. Studies were conducted according to the standardized WHO protocol for the assessment of the efficacy of anti-malarial treatment. Differences between categorical data were compared using the chi-square test or the Fisher's exact test where cell counts were ≤ 5. Differences in continuous data were compared using a t-test. RESULTS: A total of 16 studies were conducted in five sentinel sites, with 459, 505 and 332 children included in 2005, 2007 and 2009, respectively. The PCR-corrected 28-day cure rates using the per-protocol analysis were between 96%-100% for artemether-lumefantrine and 94%-100% for artesunate-amodiaquine. CONCLUSIONS: Both formulations of artemisinin-based combination therapy were effective over time and no severe adverse events related to the treatment were reported during the studies.
Subject(s)

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Malaria, Falciparum / Artemisinins / Ethanolamines / Fluorenes / Amodiaquine / Antimalarials Type of study: Guideline / Screening_studies Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Africa Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2012 Type: Article Affiliation country: Togo

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Plasmodium falciparum / Malaria, Falciparum / Artemisinins / Ethanolamines / Fluorenes / Amodiaquine / Antimalarials Type of study: Guideline / Screening_studies Limits: Child, preschool / Female / Humans / Infant / Male Country/Region as subject: Africa Language: En Journal: Malar J Journal subject: MEDICINA TROPICAL Year: 2012 Type: Article Affiliation country: Togo