Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared &#945;2-adrenoceptor in the brain-gut axis of rats in the forced swimming test.

Xie, Ying; Huang, Xi; Hu, Sui-Yu; Qiu, Xin-Jian; Zhang, Ying-Jin; Ren, Ping; Wang, Yang; Ji, Hui; Zhang, Chun-Hu; Xie, Wei-Bin; He, Juan; Xie, Meng-Zhou; Huang, Hui-Yong; Liu, Zhao-Qian; Zhou, Hong-Hao

Meranzin hydrate exhibits anti-depressive and prokinetic-like effects through regulation of the shared α2-adrenoceptor in the brain-gut axis of rats in the forced swimming test.

Xie, Ying; Huang, Xi; Hu, Sui-Yu; Qiu, Xin-Jian; Zhang, Ying-Jin; Ren, Ping; Wang, Yang; Ji, Hui; Zhang, Chun-Hu; Xie, Wei-Bin; He, Juan; Xie, Meng-Zhou; Huang, Hui-Yong; Liu, Zhao-Qian; Zhou, Hong-Hao.

Affiliation

Xie Y; Laboratory of Ethnopharmacology, Institute of Integrated Traditional Chinese and Western Medicine, Xiangya Hospital, Central South University, 87 Xiangya Road, 410008 Changsha, China.

Neuropharmacology ; 67: 318-25, 2013 Apr.

Article in En | MEDLINE | ID: mdl-23063894

Subject(s)

Antidepressive Agents/therapeutic use; Brain/physiology; Coumarins/therapeutic use; Depression/drug therapy; Gastrointestinal Motility/physiology; Receptors, Adrenergic, alpha-2/physiology; Animals; Antidepressive Agents/pharmacology; Brain/drug effects; Coumarins/pharmacology; Depression/metabolism; Depression/psychology; Gastrointestinal Motility/drug effects; Gastrointestinal Tract/drug effects; Gastrointestinal Tract/physiology; Male; Neural Pathways/drug effects; Rats; Rats, Sprague-Dawley; Swimming/psychology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Receptors, Adrenergic, alpha-2 / Coumarins / Depression / Gastrointestinal Motility / Antidepressive Agents Limits: Animals Language: En Journal: Neuropharmacology Year: 2013 Type: Article Affiliation country: China

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