Synthesis and structural characterisation of selective non-carbohydrate-based inhibitors of bacterial sialidases.

Brear, Paul; Telford, Judith; Taylor, Garry L; Westwood, Nicholas J

Brear, Paul; Telford, Judith; Taylor, Garry L; Westwood, Nicholas J.

Affiliation

Brear P; Biomedical Sciences Research Complex, University of St Andrews, North Haugh, St Andrews, Fife, KY16 9ST, UK.

Chembiochem ; 13(16): 2374-83, 2012 Nov 05.

Article in En | MEDLINE | ID: mdl-23070966

Subject(s)

Enzyme Inhibitors/pharmacology; Hymecromone/analogs & derivatives; Neuraminidase/antagonists & inhibitors; Streptococcus pneumoniae/enzymology; Sulfonic Acids/pharmacology; Crystallography, X-Ray; Enzyme Inhibitors/chemical synthesis; Enzyme Inhibitors/chemistry; Hymecromone/chemical synthesis; Hymecromone/chemistry; Hymecromone/pharmacology; Models, Molecular; Molecular Structure; Neuraminidase/chemistry; Neuraminidase/metabolism; Structure-Activity Relationship; Sulfonic Acids/chemical synthesis; Sulfonic Acids/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Streptococcus pneumoniae / Sulfonic Acids / Hymecromone / Enzyme Inhibitors / Neuraminidase Language: En Journal: Chembiochem Journal subject: BIOQUIMICA Year: 2012 Type: Article Affiliation country: United kingdom

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