LGR5-positive colon cancer stem cells interconvert with drug-resistant LGR5-negative cells and are capable of tumor reconstitution.

Kobayashi, Shinta; Yamada-Okabe, Hisafumi; Suzuki, Masami; Natori, Osamu; Kato, Atsuhiko; Matsubara, Koichi; Jau Chen, Yu; Yamazaki, Masaki; Funahashi, Shinichi; Yoshida, Kenji; Hashimoto, Eri; Watanabe, Yoshinori; Mutoh, Hironori; Ashihara, Motooki; Kato, Chie; Watanabe, Takeshi; Yoshikubo, Takashi; Tamaoki, Norikazu; Ochiya, Takahiro; Kuroda, Masahiko; Levine, Arnold J; Yamazaki, Tatsumi

Kobayashi, Shinta; Yamada-Okabe, Hisafumi; Suzuki, Masami; Natori, Osamu; Kato, Atsuhiko; Matsubara, Koichi; Jau Chen, Yu; Yamazaki, Masaki; Funahashi, Shinichi; Yoshida, Kenji; Hashimoto, Eri; Watanabe, Yoshinori; Mutoh, Hironori; Ashihara, Motooki; Kato, Chie; Watanabe, Takeshi; Yoshikubo, Takashi; Tamaoki, Norikazu; Ochiya, Takahiro; Kuroda, Masahiko; Levine, Arnold J; Yamazaki, Tatsumi.

Affiliation

Kobayashi S; PharmaLogicals Research Pte. Ltd., Singapore.

Stem Cells ; 30(12): 2631-44, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23081779

Subject(s)

Colonic Neoplasms/metabolism; Colonic Neoplasms/pathology; Neoplastic Stem Cells/metabolism; Neoplastic Stem Cells/pathology; Receptors, G-Protein-Coupled/biosynthesis; Animals; Antibodies, Monoclonal/immunology; Antibodies, Monoclonal/pharmacology; Antibodies, Neoplasm/biosynthesis; Antibodies, Neoplasm/immunology; Antibody Specificity; Biomarkers/metabolism; Cell Differentiation/physiology; Cell Line, Tumor; Colonic Neoplasms/therapy; Drug Resistance, Neoplasm; Epidermal Growth Factor/immunology; Epiregulin; Female; Humans; Immunohistochemistry; Mice; Mice, Inbred NOD; Mice, SCID; Receptors, G-Protein-Coupled/immunology; Transplantation, Heterologous

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Neoplastic Stem Cells / Colonic Neoplasms / Receptors, G-Protein-Coupled Type of study: Prognostic_studies Limits: Animals / Female / Humans Language: En Journal: Stem Cells Year: 2012 Type: Article Affiliation country: Singapore

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