Changes in apparent diffusion coefficient and T2 relaxation during radiotherapy for prostate cancer.
J Magn Reson Imaging
; 37(4): 909-16, 2013 Apr.
Article
in En
| MEDLINE
| ID: mdl-23097411
ABSTRACT
PURPOSE:
To evaluate regional and temporal changes in apparent diffusion coefficient (ADC) and T2 relaxation during radiation therapy (RT) in patients with low and intermediate risk localized prostate cancer. MATERIALS ANDMETHODS:
Seventeen patients enrolled on a prospective clinical trial where MRI was acquired every 2 weeks throughout eight weeks of image-guided prostate IMRT (78 Gy/39 fractions). ADC and T2 quantification used entire prostate, central gland, benign peripheral zone, and tumor-dense regions-of-interest, and mean values were evaluated for common response trends.RESULTS:
Overall, the RT responses were greater than volunteer measurement repeatability, and week 6 appeared to be an optimum time-point for early detection. RT effects on the entire prostate were best detected using ADC (5-7% by week 2, P < 0.0125), effects on peripheral zone were best detected using T2 (19% reduction at week 6; P = 0.004) and effects on tumors were best detected using ADC (14% elevation at week 6; P = 0.004).CONCLUSION:
ADC and T2 may be candidate biomarkers of early response to RT warranting further investigation against clinical outcomes.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Prostate
/
Prostatic Neoplasms
/
Image Interpretation, Computer-Assisted
/
Image Enhancement
/
Diffusion Magnetic Resonance Imaging
/
Radiotherapy, Intensity-Modulated
Type of study:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
/
Screening_studies
Limits:
Aged
/
Humans
/
Male
/
Middle aged
Language:
En
Journal:
J Magn Reson Imaging
Journal subject:
DIAGNOSTICO POR IMAGEM
Year:
2013
Type:
Article
Affiliation country:
Canada