Redirecting cell-type specific cytokine responses with engineered interleukin-4 superkines.

Junttila, Ilkka S; Creusot, Remi J; Moraga, Ignacio; Bates, Darren L; Wong, Michael T; Alonso, Michael N; Suhoski, Megan M; Lupardus, Patrick; Meier-Schellersheim, Martin; Engleman, Edgar G; Utz, Paul J; Fathman, C Garrison; Paul, William E; Garcia, K Christopher

Junttila, Ilkka S; Creusot, Remi J; Moraga, Ignacio; Bates, Darren L; Wong, Michael T; Alonso, Michael N; Suhoski, Megan M; Lupardus, Patrick; Meier-Schellersheim, Martin; Engleman, Edgar G; Utz, Paul J; Fathman, C Garrison; Paul, William E; Garcia, K Christopher.

Affiliation

Junttila IS; Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA.

Nat Chem Biol ; 8(12): 990-8, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23103943

Subject(s)

Cytokines/physiology; Interleukin-4/analogs & derivatives; Interleukin-4/pharmacology; CD4-Positive T-Lymphocytes/metabolism; Cell Differentiation/drug effects; Cell Line; Dendritic Cells/drug effects; Flow Cytometry; Gene Expression Profiling; Humans; Immunologic Factors/pharmacology; Interleukin-4/chemistry; Mutation/physiology; Phenotype; Phosphorylation; Protein Engineering; Real-Time Polymerase Chain Reaction; Receptors, Interleukin-4/drug effects; STAT6 Transcription Factor/metabolism; Signal Transduction/drug effects; Structure-Activity Relationship

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cytokines / Interleukin-4 Limits: Humans Language: En Journal: Nat Chem Biol Journal subject: BIOLOGIA / QUIMICA Year: 2012 Type: Article Affiliation country: United States

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