Overexpression of human amyloidogenic light chains causes heart failure in embryonic zebrafish: a preliminary report.

Shin, Jordan T; Ward, Jennifer E; Collins, Patricia A; Dai, Matthew; Semigran, Hannah L; Semigran, Marc J; Seldin, David C

Shin, Jordan T; Ward, Jennifer E; Collins, Patricia A; Dai, Matthew; Semigran, Hannah L; Semigran, Marc J; Seldin, David C.

Affiliation

Shin JT; Cardiology Division, Massachusetts General Hospital, Harvard Medical School, Boston, USA. jshin1@partners.org

Amyloid ; 19(4): 191-6, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23126591

Subject(s)

Amyloidogenic Proteins/genetics; Heart Failure/pathology; Heart Ventricles/metabolism; Heart Ventricles/pathology; Myocardium/pathology; RNA, Messenger/genetics; Zebrafish/genetics; Amyloidogenic Proteins/metabolism; Amyloidosis/genetics; Amyloidosis/metabolism; Amyloidosis/pathology; Animals; Cardiomyopathies/genetics; Cardiomyopathies/metabolism; Cardiomyopathies/pathology; Disease Models, Animal; Embryo, Nonmammalian; Gene Expression; Heart Failure/metabolism; Humans; Microinjections; Myocardium/metabolism; Oxidative Stress; Phosphorylation; Zebrafish/metabolism; Zygote/growth & development; Zygote/metabolism; Zygote/pathology; p38 Mitogen-Activated Protein Kinases/genetics; p38 Mitogen-Activated Protein Kinases/metabolism

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Zebrafish / RNA, Messenger / Amyloidogenic Proteins / Heart Failure / Heart Ventricles / Myocardium Type of study: Etiology_studies Limits: Animals / Humans Language: En Journal: Amyloid Journal subject: BIOQUIMICA Year: 2012 Type: Article Affiliation country: United States

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