Hepatobiliary disposition of 17-OHPC and taurocholate in fetal human hepatocytes: a comparison with adult human hepatocytes.

Sharma, Shringi; Ellis, Ewa C S; Gramignoli, Roberto; Dorko, Kenneth; Tahan, Veysel; Hansel, Marc; Mattison, Donald R; Caritis, Steve N; Hines, Ronald N; Venkataramanan, Raman; Strom, Stephen C

Sharma, Shringi; Ellis, Ewa C S; Gramignoli, Roberto; Dorko, Kenneth; Tahan, Veysel; Hansel, Marc; Mattison, Donald R; Caritis, Steve N; Hines, Ronald N; Venkataramanan, Raman; Strom, Stephen C.

Affiliation

Sharma S; Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA, USA.

Drug Metab Dispos ; 41(2): 296-304, 2013 Feb.

Article in En | MEDLINE | ID: mdl-23129211

Subject(s)

Hepatocytes/metabolism; Hydroxyprogesterones/metabolism; Membrane Transport Proteins/metabolism; Taurocholic Acid/metabolism; 17 alpha-Hydroxyprogesterone Caproate; Adult; Age Factors; Aged; Biological Transport; Cells, Cultured; Cold Temperature; Cyclosporine/pharmacology; Female; Gestational Age; Hepatocytes/drug effects; Humans; Hydroxyprogesterones/pharmacology; Kinetics; Male; Membrane Transport Proteins/drug effects; Membrane Transport Proteins/genetics; Middle Aged; Multidrug Resistance-Associated Protein 2; RNA, Messenger/metabolism; Rifampin/pharmacology; Verapamil/pharmacology; Young Adult

Fulltext

XML

PubMed Links

Search on Google

Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Membrane Transport Proteins / Taurocholic Acid / Hepatocytes / Hydroxyprogesterones Limits: Adult / Aged / Female / Humans / Male / Middle aged Language: En Journal: Drug Metab Dispos Journal subject: FARMACOLOGIA Year: 2013 Type: Article Affiliation country: United States

Fulltext

XML

PubMed Links

Search on Google