Targeted restoration of the intestinal microbiota with a simple, defined bacteriotherapy resolves relapsing Clostridium difficile disease in mice.

Lawley, Trevor D; Clare, Simon; Walker, Alan W; Stares, Mark D; Connor, Thomas R; Raisen, Claire; Goulding, David; Rad, Roland; Schreiber, Fernanda; Brandt, Cordelia; Deakin, Laura J; Pickard, Derek J; Duncan, Sylvia H; Flint, Harry J; Clark, Taane G; Parkhill, Julian; Dougan, Gordon

Lawley, Trevor D; Clare, Simon; Walker, Alan W; Stares, Mark D; Connor, Thomas R; Raisen, Claire; Goulding, David; Rad, Roland; Schreiber, Fernanda; Brandt, Cordelia; Deakin, Laura J; Pickard, Derek J; Duncan, Sylvia H; Flint, Harry J; Clark, Taane G; Parkhill, Julian; Dougan, Gordon.

Affiliation

Lawley TD; Wellcome Trust Sanger Institute, Hinxton, United Kingdom. tl2@sanger.ac.uk

PLoS Pathog ; 8(10): e1002995, 2012.

Article in En | MEDLINE | ID: mdl-23133377

Subject(s)

Clostridioides difficile/pathogenicity; Enterocolitis, Pseudomembranous/therapy; Feces/microbiology; Intestines/microbiology; Microbial Interactions; Probiotics/therapeutic use; Animals; Clostridioides difficile/drug effects; Drug Resistance, Bacterial; Enterocolitis, Pseudomembranous/drug therapy; Enterocolitis, Pseudomembranous/microbiology; Female; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Microbial Consortia; Molecular Sequence Data; Recurrence; Vancomycin/pharmacology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Enterocolitis, Pseudomembranous / Clostridioides difficile / Probiotics / Feces / Microbial Interactions / Intestines Limits: Animals Language: En Journal: PLoS Pathog Year: 2012 Type: Article Affiliation country: United kingdom

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