Targeted nanoparticle delivery overcomes off-target immunostimulatory effects of oligonucleotides and improves therapeutic efficacy in chronic lymphocytic leukemia.

Yu, Bo; Mao, Yicheng; Bai, Li-Yuan; Herman, Sarah E M; Wang, Xinmei; Ramanunni, Asha; Jin, Yan; Mo, Xiaokui; Cheney, Carolyn; Chan, Kenneth K; Jarjoura, David; Marcucci, Guido; Lee, Robert J; Byrd, John C; Lee, L James; Muthusamy, Natarajan

Yu, Bo; Mao, Yicheng; Bai, Li-Yuan; Herman, Sarah E M; Wang, Xinmei; Ramanunni, Asha; Jin, Yan; Mo, Xiaokui; Cheney, Carolyn; Chan, Kenneth K; Jarjoura, David; Marcucci, Guido; Lee, Robert J; Byrd, John C; Lee, L James; Muthusamy, Natarajan.

Affiliation

Yu B; Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA.

Blood ; 121(1): 136-47, 2013 Jan 03.

Article in En | MEDLINE | ID: mdl-23165478

Subject(s)

Antibodies, Monoclonal, Murine-Derived/administration & dosage; Antimetabolites, Antineoplastic/therapeutic use; Leukemia, Lymphocytic, Chronic, B-Cell/therapy; Molecular Targeted Therapy; Nanoparticles/therapeutic use; Oligonucleotides, Antisense/therapeutic use; Thionucleotides/therapeutic use; Vidarabine/analogs & derivatives; Adjuvants, Immunologic/antagonists & inhibitors; Animals; Antibodies, Monoclonal, Murine-Derived/therapeutic use; Antimetabolites, Antineoplastic/pharmacokinetics; Cell Line, Tumor/transplantation; CpG Islands; Drug Resistance, Neoplasm/drug effects; Gene Expression Regulation, Leukemic/drug effects; Gene Silencing; Genes, bcl-2/drug effects; Humans; Liposomes; Mice; Mice, Inbred NOD; Mice, SCID; Nanoparticles/administration & dosage; Neoplasm Proteins/biosynthesis; Neoplasm Proteins/genetics; Oligonucleotides, Antisense/pharmacokinetics; Proto-Oncogene Proteins c-bcl-2/biosynthesis; RNA, Small Interfering/pharmacology; Rituximab; Thionucleotides/pharmacokinetics; Toll-Like Receptor 9/antagonists & inhibitors; Toll-Like Receptor 9/genetics; Toll-Like Receptor 9/immunology; Vidarabine/pharmacokinetics; Vidarabine/therapeutic use; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Thionucleotides / Vidarabine / Leukemia, Lymphocytic, Chronic, B-Cell / Oligonucleotides, Antisense / Nanoparticles / Antibodies, Monoclonal, Murine-Derived / Molecular Targeted Therapy / Antimetabolites, Antineoplastic Limits: Animals / Humans Language: En Journal: Blood Year: 2013 Type: Article Affiliation country: United States

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