Blocking glutamate-mediated signalling inhibits human melanoma growth and migration.

Song, Zhiqi; He, Chun-Di; Liu, Jing; Sun, Changkai; Lu, Ping; Li, Lili; Gao, Lili; Zhang, Yi; Xu, Yanni; Shan, Lujuan; Liu, Yuejian; Zou, Wei; Zhang, Yuan; Gao, Haiqin; Gao, Wenting

Song, Zhiqi; He, Chun-Di; Liu, Jing; Sun, Changkai; Lu, Ping; Li, Lili; Gao, Lili; Zhang, Yi; Xu, Yanni; Shan, Lujuan; Liu, Yuejian; Zou, Wei; Zhang, Yuan; Gao, Haiqin; Gao, Wenting.

Affiliation

Song Z; Dermatology Department of 1st Affiliated Hospital, Dalian Medical University, Dalian City, Liaoning Province, China. szqdalian@yahoo.com

Exp Dermatol ; 21(12): 926-31, 2012 Dec.

Article in En | MEDLINE | ID: mdl-23171453

Subject(s)

Chromones/pharmacology; Dizocilpine Maleate/pharmacology; Excitatory Amino Acid Antagonists/pharmacology; Melanoma/drug therapy; Signal Transduction/drug effects; Skin Neoplasms/drug therapy; Animals; Cell Movement/drug effects; Cell Movement/physiology; Cell Proliferation/drug effects; Female; Glutamic Acid/metabolism; HEK293 Cells; Humans; Melanoma/metabolism; Melanoma/pathology; Mice; Mice, Inbred BALB C; Mice, Nude; Microtubule-Associated Proteins/metabolism; Microtubules/drug effects; Microtubules/metabolism; Neoplasm Invasiveness/pathology; Receptors, Metabotropic Glutamate/antagonists & inhibitors; Receptors, Metabotropic Glutamate/metabolism; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/metabolism; Signal Transduction/physiology; Skin Neoplasms/metabolism; Skin Neoplasms/pathology; Xenograft Model Antitumor Assays

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Skin Neoplasms / Signal Transduction / Dizocilpine Maleate / Chromones / Excitatory Amino Acid Antagonists / Melanoma Limits: Animals / Female / Humans Language: En Journal: Exp Dermatol Journal subject: DERMATOLOGIA Year: 2012 Type: Article Affiliation country: China

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