Generation of the first structure-based pharmacophore model containing a selective "zinc binding group" feature to identify potential glyoxalase-1 inhibitors.

Al-Balas, Qosay; Hassan, Mohammad; Al-Oudat, Buthina; Alzoubi, Hassan; Mhaidat, Nizar; Almaaytah, Ammar

Al-Balas, Qosay; Hassan, Mohammad; Al-Oudat, Buthina; Alzoubi, Hassan; Mhaidat, Nizar; Almaaytah, Ammar.

Affiliation

Al-Balas Q; Department of Medicinal Chemistry and Pharmacognosy, Faculty of Pharmacy, Jordan University of Science and Technology, P.O. Box 3030, Irbid 22110, Jordan. qabalas@just.edu.jo

Molecules ; 17(12): 13740-58, 2012 Nov 22.

Article in En | MEDLINE | ID: mdl-23174893

Subject(s)

Carrier Proteins; Lactoylglutathione Lyase; Structure-Activity Relationship; Zinc/chemistry; Algorithms; Binding Sites; Carrier Proteins/chemical synthesis; Carrier Proteins/chemistry; Catalytic Domain; Databases, Factual; Humans; Lactoylglutathione Lyase/antagonists & inhibitors; Lactoylglutathione Lyase/chemistry; Molecular Docking Simulation; Molecular Structure; Protein Binding

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Structure-Activity Relationship / Zinc / Carrier Proteins / Lactoylglutathione Lyase Type of study: Prognostic_studies Limits: Humans Language: En Journal: Molecules Journal subject: BIOLOGIA Year: 2012 Type: Article Affiliation country: Jordan

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