Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations.

Zimmermann, Iwan; Marabelli, Alessandro; Bertozzi, Carlo; Sivilotti, Lucia G; Dutzler, Raimund

Zimmermann, Iwan; Marabelli, Alessandro; Bertozzi, Carlo; Sivilotti, Lucia G; Dutzler, Raimund.

Affiliation

Zimmermann I; Department of Biochemistry, University of Zürich, Zürich, Switzerland.

PLoS Biol ; 10(11): e1001429, 2012.

Article in En | MEDLINE | ID: mdl-23185134

Subject(s)

Cations, Divalent/chemistry; Ion Channel Gating; Ligand-Gated Ion Channels/antagonists & inhibitors; Prokaryotic Cells/chemistry; Acetylcholine/chemistry; Allosteric Regulation; Amino Acid Sequence; Animals; Barium/chemistry; Binding Sites; Calcium/chemistry; Cell Membrane/chemistry; Cell Membrane/physiology; Cloning, Molecular; Crystallography, X-Ray; Cysteamine/chemistry; Electrophysiological Phenomena; Escherichia coli/chemistry; Escherichia coli/genetics; HEK293 Cells; Humans; Ligand-Gated Ion Channels/chemistry; Ligand-Gated Ion Channels/physiology; Mutagenesis, Site-Directed; Patch-Clamp Techniques/methods; Prokaryotic Cells/physiology; Protein Interaction Mapping; Protein Structure, Tertiary; Xenopus laevis/physiology; Zinc/chemistry

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Prokaryotic Cells / Cations, Divalent / Ion Channel Gating / Ligand-Gated Ion Channels Limits: Animals / Humans Language: En Journal: PLoS Biol Journal subject: BIOLOGIA Year: 2012 Type: Article Affiliation country: Switzerland

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