Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells.

Maddocks, Oliver D K; Berkers, Celia R; Mason, Susan M; Zheng, Liang; Blyth, Karen; Gottlieb, Eyal; Vousden, Karen H

Maddocks, Oliver D K; Berkers, Celia R; Mason, Susan M; Zheng, Liang; Blyth, Karen; Gottlieb, Eyal; Vousden, Karen H.

Affiliation

Maddocks OD; The Beatson Institute for Cancer Research, Switchback Road, Glasgow G61 1BD, UK.

Nature ; 493(7433): 542-6, 2013 Jan 24.

Article in En | MEDLINE | ID: mdl-23242140

Subject(s)

Energy Metabolism; Neoplasms/metabolism; Neoplasms/pathology; Oxidative Stress; Serine/deficiency; Tumor Suppressor Protein p53/metabolism; Aerobiosis; Animals; Antioxidants/metabolism; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Cell Survival; Cells, Cultured; Citric Acid Cycle; Cyclin-Dependent Kinase Inhibitor p21/genetics; Cyclin-Dependent Kinase Inhibitor p21/metabolism; Disease Models, Animal; Female; G1 Phase; Glutathione/biosynthesis; Glycolysis/drug effects; HCT116 Cells; Humans; Mice; Neoplasm Transplantation; Nucleotides/metabolism; Promoter Regions, Genetic/genetics; Serine/biosynthesis; Serine/metabolism; Serine/pharmacology; Starvation; Tumor Suppressor Protein p53/deficiency; Tumor Suppressor Protein p53/genetics

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Serine / Tumor Suppressor Protein p53 / Oxidative Stress / Energy Metabolism / Neoplasms Limits: Animals / Female / Humans Language: En Journal: Nature Year: 2013 Type: Article

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